Estonia's massive covid vaccine efficacy paper
This peer-reviewed paper was published November 21, 2023 in Scientific Reports, a Nature-affiliated journal. It compares three hundred thousand Estonians, who are divided up into vaccinated, hybrid immunity, natural immunity, and no immunity groups. These groups are compared in terms of outcomes (covid infection, covid hospitalization) during the Delta wave in early 2021, and the Omicron wave in late 2021. Note that all-cause mortality was not examined between the groups.
The large number of comparisons that are made in this paper make it difficult to create a single summary conclusion; however, the authors themselves conclude that:
Provided this paper passes whatever post-publication scrutiny is brought to bear, this will alter the legal environment for further covid vaccination.
Since February 2021 we already confirm about none feasibility of these vaccines. you can pass through the draft from "Figshare, "role of intramuscularly administrable.. "
Wow, that Table 4 is quite damning to the 'vaccinate everyone as quickly as possible' approach. The authors reach a quite reasonable overall conclusion. Not surprising to see the much greater 'hesitancy' (I hate that term as used in this context) among non-Estonians. It would have been interesting if they had tried to calculate the 'number needed to vaccinate' in each context (Delta, Omicron). And yes, a *really* interesting study would chart overall mortality, not just 'covid outcomes'.