Immunoglobulin G4 and Covid mRNA vaccines

Time to shift from vaccination stats?

This topic has electrified the Substack Covid world in late December 2022, with Alex Berenson, Jessica Rose, among others weighing in on its significance. I am not an immunologist, but as a clinician take great interest in new facets of understanding regarding Covid, or Covid vaccine injury, for how to may help with healing.

As an emergency physician, I was trained in a “first responder” model of care. The prototype situation is a car accident. The first step in first response is to secure the scene. Obviously, it does little good to administer first aid to an accident victim if they (or the first responder) get run over in the process. Thus the use of flares, traffic cones, or whatever can prevent further injury. This comes before anything else.

This response, when extended to a toxin, brings the concept of source control. The classic example is pesticide poisoning. My Emergentology colleague and mentor Dr. Ian Preyra told the story of a pesticide poisoning where all the ambulance crew became sick while transporting the patient, as did the receiving emergency department personnel. The lesson here was decontaminate the patient before transport if suspecting airborne poisoning.

Extending this idea to Covid, we see its application (and over-application) in early measures such as intubation, face shields etc. etc. Applying this idea to damage mitigation from excessive therapeutics - which I perceive Covid vaccination to be, based on VAERS data from early 2021, the notion would be to prevent excessive use of mRNA vaccines. This would apply to individuals at low risk of severe complications from covid, i.e. young adults and children.

After this task is accomplished comes the question (for a first responder, at any rate) of how to deal with the consequences of mRNA vaccines.

Understanding alterations of human physiology caused by spike proteins, (plus/minus synthetic mRNA, nanolipid particles), is a large task. There are a number of differing theories on toxicity: catecholamine surge, amyloid formation, induction of platelet autoantibodies, endothelial injury, role of ACE2 receptor, role of androgens, role of micronutrients etc. To this list we can now add rising immunoglobulin G4 subsets.

It may well be the case that the rise of this subset of immunoglobulin can explain the observed dose-response relationship between mRNA Covid vaccine injections and susceptibility to Covid. Whether immunoglobulin G4 levels also turn out to be related to clotting issues is speculative at this point. In all probability, spike protein/nanolipid/mRNA toxicity will be found to have multiple modes of action, each of which will have to be addressed.

There remains in Canada approximately 15-20% of the population that continues to obtain mRNA boosters. There are also approximately 10% of parents of toddlers that continues to give mRNA Covid vaccines to their children, despite ample data from 2020 showing absence of risk of Covid for this age group. Hospital and nursing home workers in Ontario and British Columbia are still mandated to receive Covid vaccines. In this sense, there is still a role for “source control.”

However, the point is well taken by several correspondents that it is time to shift from mRNA vaccine safety to exploring mRNA vaccine injury - its nature and mitigation.