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Testosterone is my first hypothesis. Presumably this should be seen in other waus, i.e. sex ratio in cases of sudden death, increased cardiac reports associated with testosterone use, decreased cardiac reports associated with androgen blockers.

On a closely related point, Brazilian MD/PhD Flavio Cadegiani and team identified an increased rate of severe covid in men with high androgen expression, and successfully trialed androgen blockers for the treatment of covid. Whether this means that severe covid was often impairing the heart, or whether there are other ways in which testosterone affects the body in severe illness, is subject of future research and post.

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Cadegiani did amazing work on the topic of anti-androgens in the treatment of Covid, and along the way made some observations about inflammatory and thrombotic impacts of androgens in Covid. This sets me to wondering about testosterone and cardiac health…

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It makes sense that testosterone would have some bearing on this weakness seeing as you wrote that the chance of myocarditis goes up as males age. I wonder... could this also mean post-menopausal women might have more myocarditis than pre-menopausal ones? Or, by the time women are in menopause, have their hearts “toughened up,” as it were?

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